Biomarkers Predicting Alzheimer's Disease in Cognitively Normal Aging
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چکیده
منابع مشابه
Biomarkers Predicting Alzheimer's Disease in Cognitively Normal Aging
The pathophysiologic process of Alzheimer's disease (AD) begins years before the diagnosis of clinical dementia. This concept of preclinical AD has arisen from the observation of AD pathologic findings such as senile plaques and neurofibrillary tangles in the brains of people who at the time of death had normal cognitive function. Recent advances in biomarker studies now provide the ability to ...
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IMPORTANCE Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques to initiate neurodegeneration within AD-affected regions. However, some cognitively normal older individuals harbor neural injury similar to patients with AD, without concurrent Aβ burden. Such findings challenge the proposed sequence and suggest that Aβ-independent precursors underlie AD-typical neurodege...
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ژورنال
عنوان ژورنال: Journal of Clinical Neurology
سال: 2011
ISSN: 1738-6586
DOI: 10.3988/jcn.2011.7.2.60